Chao Chen Selected Research

Leukemia

3/2024	Uncovering PROTAC Sensitivity and Efficacy by Multidimensional Proteome Profiling: A Case for STAT3.
12/2021	Design, synthesis, and evaluation of proliferation inhibitory activity of novel L-shaped ortho-quinone analogs as anticancer agents.
1/2020	Fangchinoline derivatives induce cell cycle arrest and apoptosis in human leukemia cell lines via suppression of the PI3K/AKT and MAPK signaling pathway.
11/2019	Potent Cytotoxicity of Novel L-Shaped Ortho-Quinone Analogs through Inducing Apoptosis.
3/2017	Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach.
8/2016	Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach.
1/2014	A critical role of CDKN3 in Bcr-Abl-mediated tumorigenesis.

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Chao Chen Research Topics

Disease

300	Neoplasms (Cancer) 07/2024 - 07/2006
69	Infections 02/2024 - 02/2007
53	Inflammation (Inflammations) 03/2024 - 08/2009
49	Neoplasm Metastasis (Metastasis) 04/2024 - 04/2008
30	Carcinogenesis 02/2024 - 09/2011
30	Hypoxia (Hypoxemia) 09/2023 - 08/2009
27	Breast Neoplasms (Breast Cancer) 02/2024 - 09/2011
25	Fibrosis (Cirrhosis) 02/2024 - 05/2009
25	Stomach Neoplasms (Stomach Cancer) 11/2023 - 07/2008
24	Lung Neoplasms (Lung Cancer) 04/2024 - 09/2013
24	Glioma (Gliomas) 08/2023 - 09/2011
20	Hepatocellular Carcinoma (Hepatoma) 01/2024 - 01/2012
17	Pain (Aches) 04/2024 - 01/2010
17	Colorectal Neoplasms (Colorectal Cancer) 03/2024 - 06/2012
16	Schizophrenia (Dementia Praecox) 05/2024 - 08/2011
16	Parkinson Disease (Parkinson's Disease) 01/2024 - 11/2012
14	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 04/2024 - 01/2014
14	Prostatic Neoplasms (Prostate Cancer) 03/2024 - 05/2012
14	Body Weight (Weight, Body) 12/2023 - 12/2012
14	Type 2 Diabetes Mellitus (MODY) 09/2023 - 01/2015
13	Wounds and Injuries (Trauma) 04/2024 - 10/2017
12	Insulin Resistance 04/2024 - 08/2017
12	Bronchopulmonary Dysplasia 01/2024 - 11/2009
12	Hemorrhage 12/2023 - 05/2012
12	Glioblastoma (Glioblastoma Multiforme) 08/2023 - 01/2013
12	Sepsis (Septicemia) 03/2023 - 02/2007
12	Birth Weight (Birth Weights) 02/2023 - 02/2010
10	Bacterial Infections (Bacterial Infection) 01/2024 - 12/2010
10	Heart Failure 01/2024 - 05/2012
10	COVID-19 01/2022 - 01/2020
9	Psoriasis (Pustulosis Palmaris et Plantaris) 05/2024 - 01/2020
9	Brain Neoplasms (Brain Tumor) 02/2024 - 05/2013
9	Myocardial Infarction 12/2023 - 04/2010
9	Acute Lung Injury 01/2023 - 12/2013
9	Liver Neoplasms (Liver Cancer) 01/2022 - 10/2012
9	Papillary Thyroid Cancer 01/2022 - 01/2015
9	Retinopathy of Prematurity (Retrolental Fibroplasia) 10/2021 - 04/2006
8	Pancreatic Neoplasms (Pancreatic Cancer) 05/2024 - 01/2013
8	Disease Progression 04/2024 - 01/2020
8	Alzheimer Disease (Alzheimer's Disease) 03/2024 - 10/2010
8	Spinal Cord Injuries (Spinal Cord Injury) 11/2023 - 02/2014
8	Acquired Immunodeficiency Syndrome (AIDS) 12/2022 - 04/2016
7	Mitochondrial Diseases (Mitochondrial Disease) 05/2024 - 10/2012
7	Hyperthermia 04/2024 - 02/2015
7	Leukemia 03/2024 - 01/2014
7	Osteoporosis 03/2024 - 05/2013
7	Urinary Bladder Neoplasms (Bladder Cancer) 02/2024 - 03/2011

Drug/Important Bio-Agent (IBA)

91	Proteins (Proteins, Gene)FDA Link 05/2024 - 02/2007
73	Biomarkers (Surrogate Marker)IBA 05/2024 - 08/2011
55	MicroRNAs (MicroRNA)IBA 12/2023 - 05/2011
26	Messenger RNA (mRNA)IBA 11/2023 - 02/2007
25	DNA (Deoxyribonucleic Acid)IBA 12/2023 - 06/2008
24	CytokinesIBA 02/2024 - 06/2005
23	RNA (Ribonucleic Acid)IBA 12/2023 - 05/2012
23	EnzymesIBA 07/2023 - 01/2008
21	Long Noncoding RNAIBA 01/2024 - 05/2012
21	Oxygen (Dioxygen)IBA 10/2023 - 04/2006
18	Glucose (Dextrose)FDA LinkGeneric 09/2023 - 01/2013
16	Therapeutic UsesIBA 09/2023 - 02/2012
14	Immune Checkpoint InhibitorsIBA 04/2024 - 01/2019
14	Peptides (Polypeptides)IBA 11/2023 - 03/2012
14	Circular RNAIBA 08/2023 - 01/2017
13	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2023 - 08/2012
12	LipidsIBA 09/2023 - 10/2009
12	Small Interfering RNA (siRNA)IBA 01/2022 - 04/2008
11	Transcription Factors (Transcription Factor)IBA 04/2024 - 05/2013
11	Anti-Bacterial Agents (Antibiotics)IBA 01/2024 - 01/2014
11	Doxorubicin (Adriamycin)FDA LinkGeneric 06/2022 - 07/2010
10	LipopolysaccharidesIBA 03/2023 - 12/2013
10	Retinaldehyde (Retinal)IBA 01/2023 - 01/2007
10	AntibodiesIBA 08/2022 - 01/2008
10	Hemoglobins (Hemoglobin)IBA 01/2022 - 01/2013
9	Cisplatin (Platino)FDA LinkGeneric 05/2024 - 01/2017
9	BilirubinIBA 04/2024 - 07/2007
9	Insulin (Novolin)FDA Link 04/2024 - 11/2015
9	CreatinineIBA 04/2023 - 12/2012
9	Photosensitizing Agents (Photosensitizers)IBA 01/2023 - 09/2017
9	AcidsIBA 01/2023 - 06/2011
9	CollagenIBA 01/2022 - 08/2009
9	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2021 - 08/2009
8	FlavonoidsIBA 07/2024 - 10/2012
8	Amino Acids FDA Link 03/2024 - 12/2011
8	Hormones (Hormone)IBA 02/2024 - 09/2011
8	ProdrugsIBA 09/2023 - 12/2013
8	Analgesics (Analgesic Drugs)IBA 01/2023 - 01/2014
8	1-phenyl-3,3-dimethyltriazene (PDT)IBA 01/2023 - 09/2017
8	Leucine (L-Leucine)FDA Link 08/2022 - 05/2013
8	Formaldehyde (Formol)FDA Link 07/2020 - 10/2007
8	arseniteIBA 11/2019 - 01/2017

Therapy/Procedure

157	Therapeutics 05/2024 - 05/2008
31	Drug Therapy (Chemotherapy) 02/2024 - 06/2008
26	Immunotherapy 04/2024 - 12/2013
13	Radiotherapy 02/2024 - 07/2010
12	Lasers (Laser) 02/2024 - 12/2010
11	Chinese Traditional Medicine (Traditional Chinese Medicine) 08/2023 - 05/2009
11	Photochemotherapy (Photodynamic Therapy) 01/2023 - 01/2017
10	Artificial Respiration (Mechanical Ventilation) 10/2023 - 06/2005
9	Photothermal Therapy 01/2023 - 01/2017
8	Length of Stay 01/2023 - 01/2013
7	Radiofrequency Ablation 04/2024 - 01/2019